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If RFFIT titer is less than 1:5 or less than 0.5 IU/mL, a single booster dose of 1.0 ml human rabies vaccine should be administered Rabies in humans is rare in the United States, but the CDC estimates that as many as 39,000 persons receive postexposure prophylaxis annually. wound washing and antisepsis, a series of intradermal (ID) or intramuscular (IM) rabies vaccinations, and rabies immunoglobulin in WHO category III exposures. The following guidance and schedule is provided for the administration of the Post-Exposure Rabies Prophylaxis (PEP). Choice of the therapeutic schedule 6 2.2.1 Choice of rabies PEP schedule if there was complete pre-exposure vaccination in the past 6 Medical care 6 2.1. Administration Guidance and Schedule - Rabies PEP. Treating the lesion 6 2.2. 5 1.3.2 Immunocompromised patients 5 2. Introduction. 1. Rabies is a fatal zoonotic disease preventable through timely and adequate post-exposure prophylaxis (PEP) to potentially exposed persons i.e. Booster Dose Schedule a. 1.3.1 Already received a complete pre-exposure prophylaxis (PrEP) in the past. Rabies is a fatal disease caused by the rabies virus (RABV) and other lyssaviruses and responsible for an estimated 59,000 human deaths every year .Up to 99% of human cases worldwide are caused by dog bites .Although there is no cure for clinical rabies, the disease is readily preventable through timely provision of adequate post-exposure prophylaxis (PEP). Rabies continues to kill 59 000 people a year, with a vast majority of these occurring in Africa and Asia. Rabies Post-Exposure Prophylaxis (PEP) Administration Guidance and Schedule for Healthcare Providers All rabies PEP should begin with immediate thorough cleansing of all wounds with soap and water. Introduction. Rabies Prevention Guidance •Human Rabies Prevention-United States, 2008 Recommendations of Practices (ACIP) ... Rabies Post Exposure Treatment Recommendations Author: jhouse Created Date: Rabies Post-Exposure Prophylaxis Individual is Previously Immunized Documentation of complete course of pre-exposure or PEP with HDCV or PCECV with approved schedule 2 doses of Vaccine (Day 0,3) Individual Immunocompromised or taking corticosteroids, immunosuppressive agents, chloroquine Documentation of complete immunization with HDCV or Open DOCX file, 19.23 KB, for Rabies Post-Exposure Prophylaxis Schedule (DOCX 19.23 KB) Open DOCX file, 17.28 KB, for Rabies and Bats, FAQ for Physicians (DOCX 17.28 KB) Use of a Reduced (4-Dose) Vaccine Schedule for Postexposure Prophylaxis to Prevent Human Rabies, 2009 (MMWR, ACIP Updated Recommendations) Post-exposure prophylaxis includes rabies vaccine with or without rabies immune globulin. RPEP = Rabies Post-exposure Prophylaxis **As assessed by the Rabies Control Authority §Unusual circumstances may occur in rabbits and small rodents that are kept in cages outside and may have been bitten by a rabid animal. Oklahoma State Department of Health 01-2018 Revised Rabies Pre- and Post-Exposure Prophylaxis - 3 2. administration of rabies postexposure prophylaxis (PEP) are reportable events 8 . The specific regimen depends upon the patient's prior rabies vaccine history. In instances the cage protected them from more serious wounds that may have caused death. If available, a viricidal agent such as a povidone-iodine solution should be used to irrigate the wounds.

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